Table 2.
Association of VDR-FokI genotypes and alleles in healthy controls and cases, and in males and females.
| Variables | Controls n = 254 (%) | Cases n = 267 (%) | Crude OR (95% CI) p Value | Adjusted OR 1 (95% CI) p Value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Subjects n = 254 | Males n = 127 (50.0) | Females n = 127 (50.0) | All Subjects n = 267 | Males n = 149 (55.8) | Females n = 118 (44.2) | All Subjects n = 521 | Males n = 276 | Females n = 245 | All Subjects | Males | Females | ||
| VDR-FokI genotypes | FF | 101 (39.8) | 51 (40.2) | 50 (39.4) | 117 (43.8) | 71 (47.7) | 46 (39.0) | 1.18 (0.83–1.68) | 1.36 (0.84–2.19) | 0.98 (0.59–1.64) | 1.13 (0.77–1.66) | 1.40 (0.79–2.48) | 1.08 (0.62–1.88) |
| Ff | 117 (46.1) | 56 (44.1) | 61 (48.0) | 120 (44.9) | 66 (44.3) | 54 (45.8) | 0.96 (0.68–1.35) | 1.01 (0.63–1.62) | 0.91 (0.55–1.51) | 0.94 (0.64–1.38) | 0.97 (0.55–1.72) | 0.81 (0.47–1.39) | |
| ff | 36 (14.2) | 20 (15.7) | 16 (12.6) | 30 (11.2) | 12 (8.1) | 18 (15.3) | 0.77 (0.46–1.29) | 0.47 (0.22–1.00) p = 0.047 | 1.25 (0.60–2.58) | 0.89 (0.50–1.58) | 0.48 (0.19–1.20) | 1.34 (0.61–2.92) | |
| VDR-FokI alleles | F | 319/508 (62.8) | 158/254 (62.2) | 161/254 (63.4) | 354/534 (66.3) | 208/298 (69.8) | 146/236 (61.9) | 1.17 (0.90–1.50) | 1.40 (0.99–2.00) p = 0.060 | 0.94 (0.65–1.35) | 1.10 (0.83–1.45) | 1.42 (0.93–2.17) | 0.97 (0.65–1.43) |
| f | 189/508 (37.2) | 96/254 (37.8) | 93/254 (36.6) | 180/534 (33.7) | 90/298 (30.2) | 90/236 (38.1) | 0.86 (0.67–1.11) | 0.71 (0.50–1.01) p = 0.060 | 1.07 (0.74–1.54) | 0.91 (0.69–1.21) | 0.71 (0.46–1.08) | 1.04 (0.70–1.53) | |
1 Adjusted OR: multivariate analysis; OR adjusted for age; BMI, family history, smoking, physical job demand and exposure to vibrations; Only significant p ≤ 0.05 or tendency p ≤ 0.10 were indicated.