Table 1.
The presence (+) or absence (–) of statistical associations between tissue RCAS1 expression and pathological characteristics of urothelial bladder cancer. BP: border part of tumor; CP: central part of tumor; TAMs: tumor-associated macrophages; CAFs: cancer-associated fibroblasts. TIT-tissue invasion type, NDN-nonclassic differentiation number, pT-pathological assessment of primary tumor extent, pN-pathological assessment of metastases to nearbyregional lymph nodes.
| Type of Expression and Number of Cells | Localization within Tumor | Grade | TIT | NDN | pT | pN |
|---|---|---|---|---|---|---|
| Membrane expression | BP cancer cells | − | − | − | + | + |
| p = 0.008 | p = 0.027 | |||||
| CP cancer cells | − | − | − | − | − | |
| Cytoplasmic expression | BP cancer cells | − | − | − | − | + |
| p = 0.019 | ||||||
| CP cancer cells | − | − | − | − | − | |
| BP TAMs | − | + | + | − | − | |
| p = 0.039 | p = 0.010 | |||||
| CP TAMs | – | – | – | − | − | |
| BP CAFs | + | + | + | − | − | |
| p = 0.040 | p = 0.004 | p = 0.016 | ||||
| CP CAFs | − | − | – | − | − | |
| Number of cells | BP TAMs | + | − | + | – | − |
| p = 0.032 | p = 0.008 | |||||
| CP TAMs | − | − | – | − | − | |
| BP CAFs | − | − | – | + | − | |
| p = 0.035 | ||||||
| CP CAFs | − | − | – | – | − |