Table 2.
Genetic association with coronary atherosclerosis in patients with rheumatoid arthritis (RA).
| SNP | Gene | Major, Minor Allele | Minor Allele Frequency | Odds Ratio * (95% C.I.) | p-Value |
|---|---|---|---|---|---|
| rs2073618 ** | TNFRSF11B | G,C | 0.36 | 4.09 (1.93–8.70) | 0.00026 |
| rs522616 | MMP3 | T,C | 0.29 | 4.43 (1.77–11.10) | 0.001 |
| rs2853694 | IL12B | T,C | 0.29 | 3.09 (1.53–6.24) | 0.002 |
| rs3918249 | MMP9 | T,C | 0.49 | 0.36 (0.18–0.69) | 0.002 |
| rs17576 | MMP9 | A,G | 0.45 | 0.34 (0.17–0.68) | 0.002 |
| rs3918253 | MMP9 | C,T | 0.28 | 0.38 (0.20–0.72) | 0.003 |
| rs2274756 | MMP9 | G,A | 0.16 | 0.24 (0.09–0.64) | 0.004 |
| rs751271 | NOD2 | T,G | 0.49 | 2.57 (1.33–4.96) | 0.005 |
| rs650108 | MMP3 | G,A | 0.41 | 2.82 (1.29–6.17) | 0.009 |
| rs1800947 | CRP | C,G | 0.04 | 5.93 (1.43–24.71) | 0.014 |
| rs9562414 | TNFSF11 | A,G | 0.06 | 0.25 (0.08–0.79) | 0.019 |
| rs2107545 | MPO | T,C | 0.26 | 0.42 (0.20–0.89) | 0.023 |
| rs3745367 | RETN | G,A | 0.39 | 0.45 (0.22–0.91) | 0.026 |
| rs10954213 | IRF5 | G,A | 0.47 | 0.50 (0.27–0.94) | 0.030 |
| rs633137 | TNFSF11 | T,A | 0.08 | 0.34 (0.13–0.91) | 0.031 |
| rs2243828 | MPO | A,G | 0.23 | 0.43 (0.20–0.96) | 0.040 |
| rs1801274 | FCGR2A | A,G | 0.43 | 0.52 (0.28–1.00) | 0.049 |
* Odds ratios for the comparison between minor and major allele; SNP = single-nucleotide polymorphism; C.I. = confidence interval; ** rs2073618 is the only SNP that remains significant after false discovery rate (FDR) correction.