Table 1.
Literature Review of Growth and Development for Individuals with Chromosome 15q11.2 BP1–BP2 Microdeletion Syndrome.
| Feature | Murthy et al. [15] | Doornbos et al. [16] | Von der Lippe et al. [34] | Burnside et al. [13] | Abdelmoity et al. [17] | Madrigal et al. [33] | Wong et al. [35] | Cafferkey et al. [18] | Usrey et al. [36] | Rudd et al. [37] | Jerkovich & Butler [14] | Total (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IUGR 1 | 0/1 | 3/9 | 0/5 | N/A | N/A | N/A | 1/2 | N/A | 0/2 | 0/2 | 0/1 | 4/22 (18) |
| Short stature | 0/1 | 1/9 | 1/5 | N/A | N/A | N/A | 0/2 | N/A | 0/2 | N/A | 0/1 | 2/20 (10) |
| Microcephaly | 0/1 | 1/9 | 0/5 | N/A | 4/16 | 2/2 | 0/2 | N/A | 1/2 | N/A | 1/1 | 9/38 (24) |
| Macrocephaly | 0/1 | 0/9 | 1/5 | N/A | 2/16 | 0/2 | 0/2 | N/A | 0/2 | N/A | 0/1 | 3/38 (8) |
| Developmental delay (general) | 2/2 | 7/8 | 4/7 | 33/56 | 13/15 * | 2/2 | 0/2 | 65/77 | N/A | 0/2 | 0/1 | 126/172 (73) |
| Motor delay | 1/2 | 8/9 | 5/7 | 20/56 | N/A | 2/2 | 1/2 | 29/77 | N/A | 0/2 | 0/1 | 66/158 (42) |
| Speech delay | 2/2 | 8/8 | 5/5 | 44/49 | N/A | 2/2 | 0/2 | 37/77 | N/A | 0/2 | 1/1 | 99/148 (67) |
1 Intrauterine growth retardation; * indicated both Intellectual disability or Global developmental delay; Bold indicate categories that represent 50% or greater incidence within the literature.