Table 2.
Single single-nucleotide polymorphisms (SNPs) in estrogen biosynthesis genes and association with breast cancer.
| Gene | SNPs | Alleles | Codominant Model | ptrend | Additive Model | ||||
|---|---|---|---|---|---|---|---|---|---|
| Common/Rare | Heterozygote OR (95% CI) a | p a | Homozygote OR (95% CI) a | p a | Rare Allele OR (95% CI) a | p a | |||
| CYP17A1 | rs743572 | G/A | 1.287 (0.978–1.694) | 0.072 | 1.081 (0.756–1.547) | 0.669 | 0.531 | 1.074 (0.902–1.278) | 0.424 |
| HSD17B1 | rs615942 | G/T | 0.927 (0.694–1.237) | 0.605 | 1.077 (0.760–1.526) | 0.676 | 0.905 | 1.031 (0.866–1.227) | 0.735 |
| CYP19A1 | rs2414096 | G/A | 1.099 (0.833–1.451) | 0.504 | 1.133 (0.787–1.630) | 0.503 | 0.441 | 1.065 (0.896–1.267) | 0.457 |
| CYP19A1 | rs2445759 | G/T | 0.888 (0.359–2.193) | 0.796 | 1.815 (0.153–21.572) | 0.637 | 0.945 | 1.038 (0.471–2.288) | 0.926 |
| CYP19A1 | rs2446405 | T/A | 0.957 (0.712–1.286) | 0.769 | 0.830 (0.579–1.188) | 0.307 | 0.458 | 0.919 (0.774–1.091) | 0.336 |
| CYP19A1 | rs700519 | C/T | 0.723 (0.541–0.965) | 0.028 | 0.845 (0.342–2.085) | 0.715 | 0.047 | 0.772 (0.600–0.993) | 0.044 |
| CYP19A1 | rs10046 | T/C | 0.785 (0.587–1.051) | 0.103 | 0.748 (0.527–1.064) | 0.106 | 0.074 | 0.866 (0.729–1.028) | 0.100 |
| CYP19A1 | rs749292 | G/A | 0.994 (0.746–1.326) | 0.970 | 1.100 (0.777–1.557) | 0.593 | 0.627 | 1.045 (0.880–1.241) | 0.618 |
| CYP19A1 | rs936306 | G/A | 0.869 (0.672–1.125) | 0.287 | 0.869 (0.574–1.317) | 0.508 | 0.386 | 0.908 (0.755–1.092) | 0.305 |
| CYP19A1 | rs1008805 | T/C | 0.990 (0.766–1.278) | 0.936 | 1.138 (0.736–1.758) | 0.561 | 0.799 | 1.036 (0.860–1.248) | 0.712 |
| CYP19A1 | rs11575899 | TCT/DEL | 1.029 (0.797–1.328) | 0.826 | 0.954 (0.612–1.487) | 0.837 | 0.883 | 1.001 (0.830–1.207) | 0.992 |
Abbreviation: OR, Odds Ratio; 95% CI, 95% confidence interval; Significant values are marked in bold; a Adjusted by age.