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. 2012 Mar 25;7(9):652–658. doi: 10.3969/j.issn.1673-5374.2012.09.002

Figure 6.

Figure 6

Schisandrin B protects PC12 cells from Aβ25-35 induced injury via regulation of amyloid precursor protein (APP) and vacuolar protein sorting 35 (VPS35). VPS35 is an important upstream source of APP, and VPS35 may regulate APP. Its mechanism may be as follows,

(A) VPS35 could hinder the process of APP hydrolysis into Aβ by reducing its cargo protein SorLA; (B) VPS35 could extend the transport time of its cargo protein APP from the endosome to the TGN, to reduce its degradation in the cell membrane.

Aβ: Amyloid β protein; SNX: sorting nexin; SorLA: sorting protein related receptor; BACE: β-site APP cleaving enzyme; TGN: trans Golgi network.

In summary, 5, 10, and 25 μM Schisandrin B antagonizes Aβ25-35 injury to PC12 cells in a dose-dependent manner. This is achieved through decreasing the expression of APP and sorting protein VPS35.