[Table/Fig-5]:

Autosomal recessive LGMDs

Disease	Clinical features	Locus or gene
LGMD 2A	Onset 1st or 2nd decade, Tight heel cords, contractures at elbows, wrists, fingers, rigid spine, proximal and distal weakness	Calpain 3
LGMD 2B	Onset 2nd or 3rd decade, proximal muscle weakness at onset, later calf muscles affected. Miyoshi myopathy is variant of LGMD 2B with calf muscles affected at onset [3]	Dysferlin
LGMD 2C-F	Onset in childhood to teenage. Clinical condition similar to Duchenne and Becker muscular dystrophies, cardiomyopathy uncommon, cognitive function normal.	sacroglycans
LGMD 2G	Onset age 10-15 yrs, proximal and distal muscle weakness [3]	Telethonin
LGMD 2H	Onset 1st to 3rd decade, proximal muscle weakness	TRIM 32 gene
LGMD 2I	Onset 1st to 3rd decade. Clinical condition similar to Duchenne or Becker dystrophies, cardiomyopathy, cognitive function normal.	Fukutin related protein
LGMD 2J	Onset 1st to 3rd decade, proximal lower limb weakness, mild distal weakness, progressive weakness causes loss of ambulation	Titin
LMGD 2K	Usually presents in infancy as Walker Wanrburg syndrome but can present in early adult life with proximal weakness and only minor CNS abnormalities	POMT 1
LGMD 2IL	Presents in childhood or adulthood. May manifest with quadriceps atrophy and myalgia. Some present with early involvement of the calves in the second decade of life, resembling Miyoshi myopathy	Anoctamin 5
LGMD 2M	Usually presents in infancy as Fukuyuma congenital muscular dystrophy but can present in early adult life with proximal weakness and only minor CNS abnormalities	Fukutin
LGMD 2 N	Usually presents in infancy as Muscle-Eye-Brain disease but can present in early adult life with proximal weakness and only minor CNS abnormalities	POMGn T1
LGMD 2O	Usually presents in infancy as Walker Warburg syndrome but can present in early adult life with proximal weakness and only minor CNS abnormaliies	POMT2