Table 4.

Common drug-drug interactions in cardiac transplantation.

Drug Levels	Increased by	Decreased by
Cyclosporine A (CYA) Tacrolimus (TAC)	Amiodarone Antidepressants: fluoxetine, fluvoxamine, nefazodone Antimicrobial (macrolides): clarithromycin, erythromycin Azole antifungal agents: fluconazole, ketoconazole, itraconazole, voriconazole Calcium channel blockers: diltiazem, verapamil, nifedipine, amlodipine, felodipine, nicardipine Statins: atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin Other lipid-lowering agents: ezetimibe Methylprednisolone (high dose) Metoclopramide Oral contraceptives Grapefruit juice	Antacids Anticonvulsants: phenytoin, phenobarbital, carbamazepine Antimicrobial: rifampin, isoniazid Antiplatelets: clopidogrel, ticlopidine Fibrates: gemfibrozil, fenofribrate Omeprazole St. John’s Wort
Sirolimus Everolimus	Diltiazem Azole antifungal agents: fluconazole, ketoconazole, itraconazole, voriconazole CYA
Mycophenolate Mofetil		CYA, TAC Cholestyramine Iron/antacids
Azathioprine	Allopurinol