Table 5.

Comparison of device characteristics and indications for currently approved first- through third-generation LVADs

	First-Generation	Second-Generation	Third-Generation
Flow Profile	Pulsatile	Continuous (Axial)	Continuous (Centrifugal)
Device Example	HeartMate XVE	HeartMate II	HeartWare HVAD
Device Size	1150 grams	290 grams	160 grams
Recommended Anticoagulation	Aspirin Only	Aspirin + Coumadin	Aspirin + Coumadin
Power Source	Pneumatic or Electric	Electric	Electric
Implant Site	Abdomen	Abdomen/Chest	Pericardium
Approved Indication	BTT, DT	BTT, DT	BTT

Abbreviations: BTT – bridge-to-transplant, DT – destination therapy