Figure 1. Adjuvant-independent sensitization to peanut through epicutaneous exposure.

Mice were topically exposed to 1 mg CPE or soy extract weekly for 6 weeks. Antigen-specific (A) IgE and (B) IgG1 were measured prior to allergen challenge. Black circles represent values in naive mice, and gray rectangles represent mice exposed to the extract. Mice were challenged with 0.1 mg CPE by intraperitoneal challenge. Body temperature prior to challenge and 30 minutes after the last challenge are shown in C. **P < 0.01.