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. 2014 Oct 8;124(11):4965–4975. doi: 10.1172/JCI75660

Figure 2. Peanut and Ara h 2 induce bystander sensitization, demonstrating adjuvant activity.

Figure 2

(A–C) Mice were exposed to 0.1 mg ALA on the ear, alone, or in the presence of 10 μg SEB or 1 mg CPE once a week for 6 weeks. ALA-specific (A) IgE and (B) IgG1 were measured in serum prior to oral challenge with ALA. (C) Body temperature was measured at baseline and 30 minutes after challenge. n = 5 mice per group. (D–F) The experiment was repeated with exposure to ALA in the presence or absence of 0.1 mg purified Ara h 2. n = 4 per group. *P < 0.05, **P < 0.01, ***P < 0.001, vs. ALA alone.