Skip to main content
. 2014 Sep 24;124(11):4823–4828. doi: 10.1172/JCI77685

Figure 3. Adult erythropoiesis in the absence of Sphk enzymes.

Figure 3

(A) Lethally irradiated WT mice were reconstituted with control (Ctl) or RBC Sphk dKO (KO) fetal liver cells. Peripheral blood cell counts for the transplanted mice. HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW-SD, red cell distribution width-standard deviation; RDW-CV, red cell distribution width-coefficient of variation; RET, reticulocytes; PLT, platelets; PDW, platelet distribution width; MPV, mean platelet volume. (B) Eosin staining and transmission electron microscopy images of rbc. Original magnification, ×63 and ×15,000, respectively. Plasma and rbc S1P levels in (C) transplanted mice, (D) WT and Sphk1fl/fl Sphk2+/– Epor-Cre mice, and (E) Sphk1fl/fl Sphk2–/– and EC Sphk dKO mice. n = 3 per group. **P < 0.01. All data represent the mean ± SD.