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. 2014 Oct 20;124(11):4941–4952. doi: 10.1172/JCI76864

Figure 1. Increased VEGF expression in decidual cells and sFLT1 expression in adjacent EVTs in preeclamptic women.

Figure 1

(A–H) VEGF and sFLT1 mRNA expression by ISH (basal plate). Dashed lines demarcate the border between decidua (De) and placenta. Vi, villi. In specimens from both control and preeclamptic (PE) women, VEGF was expressed specifically in maternal decidual cells (A, E, C, and G), and sFLT1 in adjacent EVTs (arrowheads; B, F, D, and H), but levels of both were dramatically elevated in preeclamptic specimens. (I–L) VEGF (I) and sFLT1 (K) ISH and CK7 IHC (J and L; sections adjacent to I and K). (M–P) VEGF (M), sFLT1 (N), PLGF (O), and VEGFB (P) total mRNA levels in placental basal plate samples from control and preeclamptic women, determined by qPCR. In preeclampsia, while levels of both VEGF and sFLT1 significantly increased, PLGF significantly decreased, and VEGFB remained unchanged. Results are mean ± SD. *P < 0.05 (n = 15). Scale bars: 100 μm.