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. 2014 Oct 20;124(11):5042–5056. doi: 10.1172/JCI71385

Figure 1. Axonal injury in the spinal cords of EAE mice induces gene expression changes in the motor cortices.

Figure 1

(A) Expression of GFAP and IBA-1 in the motor cortices (mc) of healthy and EAE mice is consistent with induction of a glial response in EAE cortices. Nuclei were visualized with DAPI (blue). Scale bar: 100 μm (left); 25 μm (left inset); 200 μm (right); 50 μm (right inset). (B) Fold changes (P < 0.05) of genes encoding ECM-related proteins differentially expressed in the motor cortices of EAE mice compared with healthy controls identified with microarray analysis. (C) Gene expression changes (mean ± SEM, qRT-PCR) for indicated transcripts in the motor cortices of EAE mice (n = 4–8 per group) relative to healthy control mice (dotted line). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, Student’s t test.