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. 2014 Oct 20;124(11):5057–5073. doi: 10.1172/JCI71882

Figure 1. RBP-J deficiency rescues the osteopetrotic bone phenotype in both Dap12–/– and Dap12–/–Fcrg–/– mice.

Figure 1

(A) Microcomputed tomography (μCT) images of trabecular bones of the distal femurs isolated from the indicated bone marrow chimeric mice. Top of images is toward the growth plate. Scale bar: 1 mm. (B) Bone morphometric analysis of femurs isolated from the chimeric mice. BV/TV, bone volume per tissue volume; Tb. N, trabecular number; Tb. Th, trabecular bone thickness; Tb. Sp, trabecular bone spacing. n = at least 5 per group. *P < 0.05; **P < 0.01. (C) Concentration of basal serum TRAP obtained from the chimeric mice. n = at least 5 per group. *P < 0.05; **P < 0.01. (D) TRAP staining and (E) Histomorphometric analysis of the histological sections obtained from the metaphysis region of distal femurs of the chimeric mice, N. Oc./BS, number of osteoclasts per bone surface; Oc. S/BS, osteoclast surface per bone surface. n = 5 per group. *P < 0.05; **P < 0.01. Scale bar: 100 μm.