Skip to main content
. 2014 Oct 8;124(11):5013–5026. doi: 10.1172/JCI76412

Figure 6. Role of NCoA2 in PCa.

Figure 6

(A) Kaplan-Meier plot indicates the association of NCoA2 signature with PSA recurrence and disease-specific death in patients with PCa (using dataset GSE10645; ref. 30), with the top third, middle third, and bottom third of patients representing inferred NCoA2 activities from high to low (P values by log-rank test and univariate Cox). (B) Model of NCoA2 in prostate tumorigenesis. ADT induces NCoA2 expression, which in turn activates PI3K/AKT signaling (via negative regulation of FKBP5, PHLPP1, and PTEN) and MAPK signaling (via positive regulation of MAP3K1, Rac-GEF, and others) that together promote PCa metastasis and CRPC.