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. 2014 Sep 24;124(11):4753–4758. doi: 10.1172/JCI76838

Figure 1. PTN treatment improves the survival of irradiated mice and hematopoietic cell transplant recipients.

Figure 1

(A) Survival of 700 cGy–irradiated mice treated intraperitoneally with 2 or 4 μg PTN or saline administered at +24 hours and every other day through day +14 (PTN-treated groups: 12 of 15 for both; saline-treated group: 5 of 15 mice; P = 0.002 for PTN 4 μg vs. saline, P = 0.004 for PTN 2 μg vs. saline). (B) Flow cytometric analysis of BM KSL cells from irradiated mice at day +10 treated with saline or PTN. (C) BM KSL cells and CFCs per femur (n = 6, *P = 0.02, **P = 0.0003). (D) Survival of irradiated mice treated subcutaneously, beginning at +48 hours and +96 hours, with PTN or saline (PTN 48 hours: 15 of 15 mice and PTN 96 hours: 13 of 15 mice; saline: 10 of 19 mice; P = 0.002 for PTN 48 hours vs. saline, P = 0.04 for PTN 96 hours vs. saline.). (E) Survival of irradiated mice transplanted with BM cells and treated with PTN or saline (PTN, 19 of 38 mice, 50% vs. saline, 6 of 36 mice, 17%; P = 0.003). (F) CFCs per femur at day +14 following transplantation and treatment with PTN or saline (n = 6, *P = 0.005). (G) H&E images (original magnification, ×63) of femurs at day +14 from transplanted mice treated with PTN or saline.