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. 2014 Sep 24;124(11):4737–4752. doi: 10.1172/JCI76375

Figure 3. Postpartum involution increases metastasis of ppBCs in a MerTK-dependent manner.

Figure 3

(A) Left panels: Representative images of histological lung sections harvested from 98-day-old virgin and parous mice harboring orthotopic allografts of mammary tumor cells (corresponding to 38 days after tumor cell injection in both groups and corresponding to Inv d33 in the parous group). Mice were treated with BMS-777607 for 7 days beginning at 64 days of age (corresponding to Inv d1 in the parous group). Right panels: Metastatic burden was quantified from H&E-stained lung sections from all 5 lung lobes in each mouse. P < 0.01 by Student’s t test. Original magnification, ×40. (B and C) Left panels: Representative histological lung sections from virgin (B) and parous (C) MerTK+/+PyVmT and MerTK–/–PyVmT mice. Original magnification, ×40. Right panels: Metastatic burden was quantified from H&E-stained lung sections from all 5 lung lobes in each mouse. P values were calculated by Student’s t test.