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Obesity and inflammation down-regulate TCA cycle and anaplerotic reaction enzyme gene expression. A, Expression of TCA cycle metabolism genes in 3T3-L1 adipocytes treated with or without 1 nM TNFα for 24 hours. Expression of TCA cycle genes in inguinal white adipose tissue (B) and epididymal white adipose tissue (C) from low-fat or high-fat fed C57BL/6J mice. Error bars represent SEM. *, P < .05 (n = 6–12 per group).
