Table 1.
Summary of biological and clinical data and history of treatment of a patient coinfected by HIV and autochthonous Leishmania in Martinique
| January of 2007 | May of 2007 | January of 2008 | August of 2008 | February of 2009 | June of 2009 | January of 2010 | August of 2010 | January of 2011 | November of 2011 | February of 2012 | June of 2012 | January of 2013 | July of 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV-1 viral load (copies/mL) | 1.6 × 106 | 485 | 49 | 40 | < 40 | < 40 | < 20 | < 20 | < 20 | 27 | < 20 | < 20 | < 20 | < 20 |
| CD4 count (/μL) | 186 | 663 | 290 | 218 | 187 | 211 | 244 | 151 | 109 | 133 | 287 | 381 | 412 | 362 |
| Lymphocytes (/μL) | 1,280 | 2,210 | 1,285 | 1,830 | 1,367 | 949 | 833 | 939 | 1,624 | 2,409 | 2,613 | 2,061 | ||
| Total leukocytes (/μL) | 4,580 | 5,530 | 4,200 | 3,650 | 5,350 | 4,130 | 3,110 | 2,730 | 5,230 | 3,610 | 5,920 | 7,250 | ||
| Hemoglobin (g/dL) | 13 | 11 | 11 | 11 | 10 | 11 | 9 | 9 | 9 | 6 | 9 | 10 | 12 | 11 |
| Platelet count (× 109/L) | 166 | 214 | 206 | 220 | 250 | 216 | 201 | 152 | 241 | 111 | 273 | 300 | ||
| Clinical manifestations | HSM and WL | |||||||||||||
| Others investigations | BM+, bPCR+ | bPCR– | bPCR– | bPCR– | ||||||||||
| Serology IFA (retrospective) | 1/640 | 1/640 | 1/320 | 1/320 | 1/320 | |||||||||
| Serology ELISA (retrospective) | + | + | + | + | + | |||||||||
| Red blood cells transfusion | ||||||||||||||
| Antibiotic | SMX-TMP | SMX-TMP | ||||||||||||
| cART | cART 1: ABC/3TC/LPV/r | cART 2: ABC/3TC/EFV | ||||||||||||
| Amphotericin B | Yes | |||||||||||||
ABC = abacavir; BM = bone marrow biopsy and aspiration; bPCR = blood Leishmania PCR; EFV = efavirenz; HSM = hepatosplenomegaly; LPV/r = lopinavir plus ritonavir; WL = weight lost; 3TC = lamivudine.