Table 5.
Animal identification | Days after inoculation (PRNT50 titers by BHK, FcγR-expressing BHK cells) | ||||||
---|---|---|---|---|---|---|---|
0* | 2 | 4 | 7 | 11 | 15 | 21 | |
Group A (mAb 4G2) | |||||||
A1 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, 10 | 10, 10 | 10, 10 | 20, 10 |
A2 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, < 10 | 10, 20 | 10, 10 | 10, ND |
A3 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, < 10 | 20, 20 | 10, 10 | 10, 10 |
Group B (mAb 6B6C) | |||||||
B1 | 10, < 10 | 10, < 10 | 10, < 10 | 10, < 10 | 10, 10 | ND, 10 | 40, 10 |
B2 | 10, < 10 | 10, < 10 | < 10, < 10 | < 10, < 10 | ND, ND | 10, 10 | 40, 10 |
B3 | < 10, < 10 | < 10, < 10 | 10, < 10 | 10, < 10 | 10, 20 | 20, 10 | 10, ND |
Control (saline) | |||||||
C1 | < 10, < 10 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 20, 20 | 10, 10 | 20, 10 |
C2 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, 10 | ND, ND | 10, 10 | 160, 10 |
C3 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, < 10 | ND, ND | 10, 10 | 40, 20 |
C4 | < 10, < 10 | < 10, < 10 | < 10, < 10 | 10, < 10 | ND, ND | 10, 10 | 80, 40 |
Results are shown as reciprocal of the highest plasma dilution (end-point titer) that results in < 50% input of plaque count and were expressed as PRNT50 values. ND = not determined because of low sample volumes.
Values after Ab or saline administration.