Table 6.
Levels of dengue viral RNA in plasma samples from marmosets treated with mouse Ab or saline and inoculated with DENV-2
| Animal identification | Administered Ab/saline | Inoculated virus dose (PFU/dose) | Dengue viral RNA copy numbers (log10 copies/mL) days after inoculation | |||||
|---|---|---|---|---|---|---|---|---|
| 0* | 2 | 4 | 7 | 11 | 15 | |||
| Group A | ||||||||
| A1 | mAb 4G2 | 1 × 105 DENV-2 | − | 6.0 | 6.9 | 5.7 | − | − |
| A2 | mAb 4G2 | 1 × 105 DENV-2 | − | 6.3 | 6.5 | 4.6 | − | − |
| A3 | mAb 4G2 | 1 × 105 DENV-2 | − | 5.9 | 6.4 | 4.9 | − | − |
| Group B | ||||||||
| B1 | mAb 6B6C | 1 × 105 DENV-2 | − | 5.5 | 5.9 | 5.5 | − | − |
| B2 | mAb 6B6C | 1 × 105 DENV-2 | − | 6.0 | 6.4 | 6.0 | − | − |
| B3 | mAb 6B6C | 1 × 105 DENV-2 | − | 6.0 | 6.4 | 4.6 | 3.6 | − |
| Control | ||||||||
| C1 | Saline | 1 × 105 DENV-2 | − | 6.2 | 6.7 | 5.4 | 4.0 | − |
| C2 | Saline | 1 × 105 DENV-2 | − | 6.4 | 6.9 | 4.5 | − | − |
| C3 | Saline | 1 × 105 DENV-2 | − | 6.3 | 6.6 | 4.7 | 3.6 | − |
| C4 | Saline | 1 × 105 DENV-2 | − | 6.2 | 6.7 | 4.7 | 3.2 | − |
Viral RNA below detection levels is indicated by –.
*
Levels of viral genome were quantitated using plasma samples from marmosets after passive transfer of mouse mAb but before DENV inoculation.