Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 3;9:32. doi: 10.3389/fnins.2015.00032

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Liddelow.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Biondi ring tangles in aged human choroid plexus of the lateral and fourth choroid plexus. (A) Fluorescent light micrograph of thioflavin S-stained Biondi ring tangles (arrows) in the choroid plexus of the brain of a 78-year-old human female with Alzheimer's disease showing Biondi ring tangles appear as ring, tangle, serpentine, and curled profiles. (Magnification: 530×). (B) Scanning electron micrograph (Magnification 2500 ×) showing destruction of plexus epithelial cell containing ring-like Biondi inclusions. Arrow marks a ring bursting from an individual plexus epithelial cell. Material from 78 year old woman. (C) Electron micrograph of a choroid plexus from a 70-year-old male with Alzheimer's disease showing the fibrous Biondi ring tangles (one highlighted in pink, the other in green) associated with lipofuscin granules, mitochondria, and other cellular components. (Magnification: 10,300×). (A,C) Reproduced from Wen et al., 1999 Copyright © 1999 Elsevier Science B.V. All rights reserved. (B) Reproduced from (Kiktenko, 1986) Copyright © 1986 Springer All rights reserved. Abbreviations: BV, blood vessel; CPEC, choroid plexus epithelial cell; CSF, cerebrospinal fluid; N, nucleus.