Table 6.
Multivariate Linear Regression Examining the Association of Pulmonary Function with Th-Cell Responses
| Pulmonary Function Indices* | Unadjusted Analysis β† (95% CI) (P Value) | Adjusted Analysis‡ β† (95% CI) (P Value) |
|---|---|---|
| FEV1/FVC ratio | 1.18 (−0.41 to 2.78) (0.14) | — |
| RV | −8.56 (−16.56 to −0.56) (0.04) | −7.03 (−14.83 to 0.77) (0.08) |
| RV/TLC ratio | −1.76 (−3.07 to −0.45) (0.01) | −1.31 (−2.55 to −0.08) (0.04) |
| Expiratory reserve volume | −3.42 (−7.95 to 1.10) (0.14) | — |
| FRC | −5.30 (−9.54 to −1.06) (0.02) | −3.39 (−7.45 to 0.68) (0.10) |
| Inspiratory capacity | 4.20 (0.67 to 7.73) (0.02) | 1.82 (−1.41 to 5.07) (0.27) |
Definition of abbreviations: CI = confidence interval; RV = residual volume.
Percent predicted values of pulmonary function indices were included in the analysis other than percent FEV1/FVC ratio.
β represents a unit change in pulmonary function index with unit change in log10 Th1/Th2 ratio in response to Dermatophagoides farinae.
Adjusted for homeostatic model assessment of insulin resistance, with age, sex, ethnicity, and body mass index z score included as pertinent covariates. Multivariate linear regression analysis was performed only when a significant association was observed between Th-cell response and pulmonary function index in univariate analysis.