Table 7.
Multivariate Linear Regression Examining the Association of Pulmonary Function with CCR2 Expression on Classical Monocytes
| Pulmonary Function Indices* | Unadjusted Analysis β† (95% CI) (P Value) | Adjusted Analysis‡ β† (95% CI) (P Value) |
|---|---|---|
| FEV1/FVC ratio | −0.02 (−0.15 to 0.11) (0.76) | — |
| RV | 0.84 (0.20 to 1.47) (0.01) | 0.66 (0.09 to 1.24) (0.03) |
| RV/TLC ratio | 0.10 (−0.01 to 0.21) (0.06) | — |
| Expiratory reserve volume | 0.25 (−0.12 to 0.62) (0.18) | — |
| FRC | 0.46 (0.11 to 0.80) (0.009) | 0.37 (0.07 to 0.68) (0.02) |
| Inspiratory capacity | 0.08 (−0.20 to 0.36) (0.57) | — |
Definition of abbreviations: CCR2 = C-C chemokine receptor type-2; CI = confidence interval; RV = residual volume.
The percent predicted values of pulmonary function indices were included in the analysis other than percent FEV1/FVC ratio.
β represents a unit change in pulmonary function index with unit change in CCR2 expression on monocyte subsets.
Adjusted for serum high-density lipoprotein, with age, sex, ethnicity, and body mass index z score included as pertinent covariates. Multivariate linear regression analysis was performed only when a significant association was observed between CCR2 expression on monocyte subsets and pulmonary function index in univariate analysis.