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. 2015 Mar 3;9:51. doi: 10.3389/fnbeh.2015.00051

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Copyright © 2015 Careaga, Tiba, Ota and Suchecki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute propranolol treatment did not modify the effect induced by acute metyrapone treatment on contextual fear memory. (A) Metyrapone treatment significantly reduced freezing on Test 1 and this effect is not modify by PROP treatment. (B) Metyrapone treatment 90 min before Test 1 reduced freezing behavior on Test 1 and this effect did not persist on subsequent tests. VEH + VEH = vehicle group (n = 10); MET + VEH = metyrapone group (n = 8); VEH + PROP = propranolol group (n = 9); MET + PROP = metyrapone and propranolol group (n = 9). *P < 0.05, compared to control group; # P < 0.05, compared to Test 1, for all groups on Test 2 and for VEH + VEH and VEH + PROP on Test 3; & P < 0.05, compared to Test 2, for MET-treated groups.