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. 2015 Mar 3;9:51. doi: 10.3389/fnbeh.2015.00051

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Copyright © 2015 Careaga, Tiba, Ota and Suchecki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute pre-test 1 metyrapone treatment had similar effects on CFC and TFC. (A) Metyrapone treatment reduced freezing on test 1 after tone exposure. (B) Metyrapone treatment reduced freezing behavior on test 1 but this effect did not persist in subsequent tests VEH + VEH = vehicle group (n = 10); MET + VEH = metyrapone group (n = 8); VEH + PROP = propranolol group (n = 9). *P < 0.05, compared to control group; § P < 0.05, comparing pre and post-tone moment. # P < 0.05, compared to Test 1, for all groups; & P < 0.05, compared to Test 2, only for MET + VEH and VEH + VEH groups.