Table 1.
Treatment design used in the behavioral experiments.
| Experiment | Administration time | Number of animals/Group | ||||||
|---|---|---|---|---|---|---|---|---|
| VEH | MET | PROP | VEH + VEH | MET + VEH | VEH +PROP | MET + PROP | ||
| Effects of acute MET treatment on retrieval and subsequent memory processing of CFC | 90 min before Test 1 | 10 | 9 | |||||
| Imediately after Test 1 | 10 | 10 | ||||||
| Effects of acute PROP treatment on retrieval and subsequent memory processing of CFC | 30 min before Test 1 | 9 | PROP2 mg/kg (8) PROP5 mg/kg (8) PROP10 mg/kg (9) |
|||||
| Effects of combined acute MET and PROP on retrieval and subsequent memory processing of CFC | MET (90 min) and PROP (30 min) before Test 1 | 10 | 8 | 9 | 9 | |||
| Imediately after Test 1 | 8 | 7 | 10 | 9 | ||||
| Four days after training without Test 1 | 9 | 8 | 9 | 8 | ||||
| Effects of acute MET and PROP on retrieval and subsequent memory processing of TFC | MET (90 min) and PROP (30 min) before Test 1 | 10 | 8 | 9 | ||||
| Effects of acute MET on non-associative fear expression | 90 min before Test | 10 | 10 | |||||
| MET effect on anxiety-like behaviors and locomotor activity | 90 min before Test | 5 | 5 | |||||
The memory tasks used, the moment of administration of the drugs and the number of animals per group are shown.