Table 1.

Multivariate analysis for the identified prognostic genes for overall survival (OS).

Variables	P-value	HR	95% CI-low	CI-high
Overall survival
LEF1 (scenario 8)	0.00642	1.58	1.14	2.19
CEBPAdmα	0.00214	0.33	0.16	0.67
FLT3ITD β	0.00025	1.77	1.30	2.40
NPM1+β	0.00005	0.51	0.37	0.71
WBC countδ, × 109/L	0.00886	1.00	1.00	1.00
Age$	0.00005	1.02	1.01	1.03
Overall survival
SFRP2 (scenario 2, 8)	0.00091	2.00	1.33	3.00
CEBPAdmα	0.00160	0.32	0.16	0.65
FLT3ITD β	0.00007	1.87	1.37	2.55
NPM1+ β	0.00006	0.52	0.38	0.71
WBC countδ, × 109/L	0.00470	1.00	1.00	1.01
Age$	0.00007	1.02	1.01	1.03
Overall survival
RUNX1 (scenario 3)	0.03768	1.38	1.02	1.88
CEBPAdmα	0.00308	0.34	0.17	0.69
FLT3ITD β	0.00023	1.78	1.31	2.41
NPM1+ β	0.00004	0.51	0.37	0.71
WBC countδ, × 109/L	0.01106	1.00	1.00	1.00
Age$	0.00001	1.02	1.01	1.03
Overall survival
PSMD2 (scenario 5, 6)	0.00220	0.60	0.43	0.83
CEBPAdmα	0.00130	0.31	0.15	0.63
FLT3ITD β	0.00006	1.87	1.38	2.55
NPM1+ β	0.00160	0.59	0.42	0.82
WBC countδ, × 109/L	0.00270	1.00	1.00	1.01
Age$	0.00009	1.02	1.01	1.03
Overall survival
XPNPEP (scenario 1)	0.00200	1.56	1.18	2.07
CEBPAdmα	0.00084	0.30	0.15	0.60
FLT3ITD β	0.00130	1.66	1.22	2.26
NPM1+ β	0.00020	0.55	0.40	0.75
WBC countδ, × 109/L	0.01190	1.00	1.00	1.00
Age$	0.00015	1.02	1.01	1.03
Overall survival
PPARD (scenario 4, 6)	0.00063	0.52	0.36	0.76
CEBPAdmα	0.00075	0.29	0.14	0.60
FLT3ITD β	0.00011	1.83	1.35	2.48
NPM1+ β	0.00084	0.57	0.41	0.79
WBC countδ, × 109/L	0.00360	1.00	1.00	1.01
Age$	0.00001	1.02	1.01	1.03
Overall survival
AXIN2 (scenario 8)	0.0038	1.79	1.21	2.66
CEBPAdmα	0.0009	0.30	0.15	0.61
FLT3ITD β	0.0003	1.77	1.30	2.40
NPM1+ β	0.0003	0.55	0.40	0.76
WBC countδ, × 109/L	0.0100	1.00	1.00	1.00
Age$	0.00004	1.02	1.01	1.03

Cox proportional hazard model for multivariable analyses of prognostic markers for overall survival. Analyses included 344 AML patients. Abbreviations: HR, hazard ratio; CI, confidence interval; α CEBPA^{double−mutation} status versus CEBPA^wt, β FLT3^ITD versus no FLT3^ITD mutation, β NPM1^mutant versus NPM1^wt, δ WBC count higher than 20 × 10⁹/L versus lower than 20 × 10⁹/L, $ Age is used as continuous variable.