Figure 3.

Aβ peptides-induced platelet activation. Aβ peptides present in plasma activate platelets inducing activation of PLC/PKC and intracellular Ca²⁺ movement, granule secretion, kinase activation, rap1b mediated-integrin activation and aggregation. Aβ peptides released from α-granules, ADP released by dense granules, and formation of TxA₂ reinforce platelet activation. Aβ peptides also promotes ROS formation, caspase activation and membrane scrambling. Activated platelets recruit leukocytes and promotes vascular inflammation.