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. 2015 Mar 2;208(5):545–562. doi: 10.1083/jcb.201406100

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© 2015 Thangavel et al.

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Figure 6. — DNA2 resects reversed replication forks. (A) Electron micrograph of a partially single-stranded (left) and entirely double-stranded (right) reversed fork observed on genomic DNA upon HU-treatment. The black arrow points to the ssDNA region on the reversed arm. Inset, magnified four-way junction at the reversed replication fork. D, Daughter strand; P, Parental strand; R, Reversed arm. (B) Frequency of fork reversal and ssDNA composition of the reversed arms in RECQ1- or DNA2-depleted U-2 OS cells treated with HU (left) or in unperturbed conditions (right). The percentage values are indicated on the top of the bar. “# RI” indicates the number of analyzed replication intermediates. Data in B are reproduced with very similar results in at least one independent experiment.