Table 2.
Infarct size (IS) results at 1.5T by quantification method and corresponding reproducibilities
| 1.5T | IS (FWHM) | IS (5SD) | IS (6SD) | IS (7SD) | IS (8SD) | IS (OAT) | IS (MANUAL) |
|---|---|---|---|---|---|---|---|
| Mean IS (%LVM) | 18.3 ± 10.7 | 25.9 ± 16.1b | 22.0 ± 15.8a | 19.8 ± 15.3 | 17.7 ± 14.4 | 28.2 ± 11.8b | 16.5 ± 10.3 |
| ICC v Manual | 0.909 | 0.667 | 0.759 | 0.804 | 0.832 | 0.621 | |
| Mean bias v Manual (±1.96SD LoA) | +1.84 (+10.30, −6.62) | +9.39 (+25.58, −6.81) | +5.57 (+21.65, −10.52) | +3.28 (+18.86, −12.30) | +1.21 (+15.92, −13.50) | +11.71 (+17.39, +6.03) | |
| Interobserver ICC | 0.922 | 0.952 | 0.904 | 0.906 | 0.888 | 0.976 | 0.793 |
| Interobserver mean bias (±1.96SD LoA) | +0.37 (+9.17, −8.43) | +2.54 (+11.62, −6.54) | +4.43 (+16.01, −7.16) | +4.00 (+15.48, −7.47) | +4.01 (+16.02, −8.01) | +0.55 (+5.82, −4.73) | +5.34 (+14.96, −4.28) |
| Intraobserver ICC | 0.991 | 0.957 | 0.954 | 0.938 | 0.925 | 0.991 | 0.983 |
| Intraobserver mean bias (±1.96SD LoA) | +0.36 (+3.34, −2.61) | −0.81 (+9.37, −10.99) | +0.01 (+10.28, −10.27) | +0.07 (+11.76, −11.62) | +0.42 (+13.00, −12.17) | +0.81 (+4.21, −2.50) | −1.92 (+0.64, −4.49) |
IS expressed as mean ± standard deviation. FWHM = full-width half maximum, 5-8SD = >5-8 standard deviation, OAT = Otsu’s Automated Thresholding, LVM = Left Ventricular Mass, ICC = Intraclass Correlation Coefficient, LoA = Limits of Agreement (Bland-Altman).
a - p < 0.05 vs. manually quantified IS. b – p < 0.01 vs. manually quantified IS.