Table 3.
Infarct size (IS) results at 3.0T by quantification method and corresponding reproducibilities
| 3 T | IS (FWHM) | IS (5SD) | IS (6SD) | IS (7SD) | IS (8SD) | IS (OAT) | IS (MANUAL) |
|---|---|---|---|---|---|---|---|
| Mean IS (%LVM) | 10.8 ± 8.2 | 17.0 ± 11.2b | 14.77 ± 10.4b | 13.0 ± 9.7a | 11.4 ± 9.0 | 21.6 ± 9.8b | 11.5 ± 9.0 |
| ICC v Manual | 0.964 | 0.780 | 0.874 | 0.937 | 0.966 | 0.505 | |
| Mean bias v Manual (±1.96SD LoA) | +0.22 (+5.09, −4.65) | +6.42 (+14.93, −2.09) | +4.17 (+11.05, −2.71) | +2.38 (+7.92, −3.16) | +0.81 (+5.62, −4.01) | +11.03 (+22.20, −0.15) | |
| Interobserver ICC | 0.990 | 0.957 | 0.937 | 0.916 | 0.888 | 0.977 | 0.913 |
| Interobserver mean bias (±1.96SD LoA) | −0.49 (+1.74, −2.72) | +0.44 (+7.23, −6.35) | +1.14 (+8.51, −6.23) | +1.40 (+9.25, −6.44) | +1.50 (+9.99, −6.98) | −0.05 (+4.35, −4.44) | +1.97 (+9.48, −5.54) |
| Intraobserver ICC | 0.988 | 0.992 | 0.992 | 0.993 | 0.993 | 0.986 | 0.972 |
| Intraobserver mean bias (±1.96SD LoA) | +0.20 (+1.49, −1.10) | +0.43 (+2.90, −2.03) | −0.04 (+2.42, −2.50) | +0.10 (+2.19, −1.98) | +0.32 (+2.08, −1.45) | +0.15 (+3.50, −3.21) | +1.14 (+4.35, −2.07) |
IS expressed as mean ± standard deviation. FWHM = full-width half maximum, 5-8SD = >5-8 standard deviation, OAT = Otsu’s Automated Thresholding, LVM = Left Ventricular Mass, ICC = Intraclass Correlation Coefficient, LoA = Limits of Agreement (Bland-Altman).
a - p < 0.05 vs. manually quantified IS. b – p < 0.01 vs. manually quantified IS.