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A tumorigenic role for PCTAIRE1. In normal tissues (left), PCTAIRE1 is required for spermatogenesis (in testis) and neuron differentiation (in brain). In cancer cells (right), PCTAIRE1 phosphorylates p27 at Ser10, thereby promoting p27 ubiquitination/degradation, which leads to cell cycle progression and decreased levels of apoptosis. Unknown mechanism(s) may also exist in the PCTAIRE1-apoptosis pathway.
