Table 3.

Effect of citrulline infusion on renal plasma flow and resulting renal citrulline delivery

	Sham (n = 7)	1–2 Wk (n = 11)	4–5 Wk (n = 7)	10–12 Wk (n = 17)
Total RPF, ml/min
Baseline	9.4±0.7	3.1±0.3†	1.3±0.3†	2.2±0.3†
Citrulline infusion	14.2±0.9	2.6±0.7†	1.9±0.5†	2.0±0.3†
	P < 0.01	NS	NS	NS
Total renal citrulline delivery, nmol/min
Baseline	632±52	324±36*	150±31†	331±53*
Citrulline infusion	2,170±271	816±182†	586±166†	630±104†

Values are means ± SE. n = No. of rats. Renal plasma flow (RPF) was measured by p-aminohippuric acid (PAH) clearance at baseline and during citrulline infusion. Sham RPF is for 2 kidneys. Renal citrulline delivery was determined by RPF × plasma citrulline concentrations. Statistics comparing each injury group with sham were done with 1-way ANOVA. Statistics comparing baseline vs. infusion were done with a paired t-test.

^*P < 0.01,

^†P < 0.001 vs. sham.