Table 4.

Citrulline uptake by the proximal tubule via filtration vs. peritubular transport

	Sham (n = 7)	1–2 Wk (n = 11)	4–5 Wk (n = 7)	10–12 Wk (n = 17)
Renal uptake, nmol/min	66±7	91±11*	32±16*	26±5*
Filtered, nmol/min	50±4	28±4*	16±3†	11±2†
Peritubular uptake, nmol/min	11±8	55±16*	17±15	7±5
% Filtered uptake	89±10	36±10†	71±13	65±15

Values are means ± SE. n = No. of rats. Filtered citrulline was calculated by citrulline delivery multiplied by filtration fraction. Peritubular uptake was calculated by total renal citrulline uptake subtracted from filtered citrulline minus excreted citrulline. Statistics comparing each injury group with sham were done with one-way ANOVA.

^*P < 0.05,

^†P < 0.01 vs. sham.