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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cell Signal. 2014 Dec 24;27(3):460–469. doi: 10.1016/j.cellsig.2014.12.011

Figure 4. Hyperglycemia enhances oxidative DNA damage in Kidney cells in Tg26 mice.

Figure 4

Renal cortical sections of control mice, hyperglycemic mice, Tg26, and hyperglycemic Tg26 mice were immunolabeled for 8-OHDG expression.

A. Representative microphotographs showing expression of 8-OHdG by kidney cells in different groups. 8-OHdG +ve nuclei are darkly stained.

B. Cumulative data on number of 8-OHDG +ve nuclei per glomerulus. *P<0.01 compared to FVBN; **compared to FVBN and FVBN +STZ.

C. Cumulative data on number of 8-OHdG +ve nuclei/tubule. *P<0.05 compared to FVBN; **P<0.01 compared to FVBN;***P<0.05 compared to Tg26.