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Freeze–thaw stability for 5-FU and MTX in mouse plasma and brain samples
| Biological matrix | Theoretical (ng/mL) | RE%a (4 h) | RE% (22 h) | ||
|---|---|---|---|---|---|
| MTX | 5-FU | MTX | 5-FU | ||
| Plasma | 31.3 | −4.0 | −11.2 | −2.0 | −26.6 |
| 125 | −16.2 | −25.1 | 3.0 | −5.6 | |
| 500 | −0.7 | −10.5 | −6.4 | −3.0 | |
| Brain | 31.3 | 15.9 | −13.1 | 7.2 | 21.3 |
| 125 | 21.2 | −8.4 | 1.5 | −7.1 | |
| 500 | −15.0 | −0.3 | −3.9 | −1.3 | |
Percentage relative error (RE %) = [(mean observed − theoretical value)/theoretical value] × 100.
