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. Author manuscript; available in PMC: 2015 Mar 3.
Published in final edited form as: J Immunol. 2012 Sep 12;189(8):4014–4023. doi: 10.4049/jimmunol.1200798

FIGURE 4.

FIGURE 4

Comparisons of amino acid differences in HLA-DPB1 binding pocket 4. Odds ratios for amino acid differences at positions 36 and 55 between cases and controls. In these figures, each datum point represents the odds ratio whereas the lines surrounding the points represent 95% confidence intervals. Comparisons were made between CBD versus control, BeS versus control, case versus control, and CBD versus BeS in (A) all subjects and (B) restricted to subjects having one or two E69 alleles. Subjects with two alanines at positions 36 and 55 are 13% less likely to have CBD than do controls, and subjects who have one alanine and one valine at position 36 and one alanine and one aspartic acid at position 55 are 51% less likely to have CBD than do controls. These associations were also evident when the analysis was restricted to subjects having one or two E69 alleles.