Skip to main content
. Author manuscript; available in PMC: 2015 Aug 5.
Published in final edited form as: Nat Commun. 2015 Feb 5;6:6219. doi: 10.1038/ncomms7219

Figure 7.

Figure 7

Summary of Treg, Tconv, and DC dynamics. (a) Cellular choreography illustrating cell dynamics and the role of CTLA using cell shapes rendered from 2P images (Tregs, green; Tconv, red; DCs, blue). Panels represent steady-state conditions (top left); inflammation (LPS DC; top right); T cell priming in three phases (middle); Tregs interacting with clusters during phase II under normal priming conditions (labeled ITC for isotype control; bottom left) and in the presence of CTLA4-blocking antibody (labeled αCTLA4; bottom right). (b) Chart of relative surface expression by Tconv cells during T cell priming. CD4 density refers to the local concentration of antigen-specific T cells near antigen-presenting DCs during phase 2. (c) Color-coded diagram of measured contact durations among Tregs and Tconvs (top panel), and among T cells and DCs (bottom panel). Each change in contact duration (different colors) represents a significant difference of at least p < 0.05.