Table 2.
Blood Gas, Brain Lesion Size and Swelling, and Markers of Endothelial Activation in Brain and Circulation
| Value | Normal saline (n=6) | Fresh frozen plasma (n=6) | p value | ||
|---|---|---|---|---|---|
| Baseline | Blood count | Hematocrit (%) | 27.8 (26.7–33-9) | 25.6 (24.7–37.8) | 0.54 |
| Blood gas | pH | 7.47 (7.45–7-49) | 7.47 (7.44–7.48) | 0.59 | |
| Lactate (mmol/L) | 1.9 (1.4–2.0) | 1.7 (1.3–2.3) | 0.94 | ||
| pO2 (mm Hg) | 101.2 (93.8–114.7) | 110.5 (98.5–111.4) | 0.39 | ||
| pCO2 (mm Hg) | 34.0 (32.5–38.5) | 37.3 (35.7–38.5) | 0.24 | ||
| Postresuscitation | Blood count | Hematocrit (%) | 16.5 (14.8–19.4) | 20.7 (18.6–21.8) | 0.04 |
| Blood gas | pH | 7.37 (7.31–7.39) | 7.42 (7.37–7.43) | 0.08 | |
| Lactate (mmol/L) | 2.9 (2.5–6.7) | 5.4 (4.4–5.8) | 0.33 | ||
| pO2 (mm Hg) | 101.8 (91.9–123.2) | 84.2 (74.5–117.5) | 0.33 | ||
| pCO2 (mm Hg) | 37.1 (26.1–39.2) | 42.6 (40.6–46.7) | 0.02 | ||
| Six-hour observation | Blood count | Hematocrit (%) | 18.2 (16.2–20-6) | 17.7 (16.0–19.8) | 0.82 |
| Blood gas | pH | 7.43 (7.39–7.45) | 7.49 (7.48–7.49) | <0.01 | |
| Lactate (mmol/L) | 1.5 (0.8–2.5) | 2.1 (1.4–2.4) | 0.24 | ||
| pO2 (mmHg) | 101.9 (95.1–107.3) | 103.4 (90.3–111.7) | 0.94 | ||
| pCO2 (mmHg) | 34.5 (28.7–36.1) | 41.7 (28.7–45.0) | 0.09 | ||
| Brain | Lesion size and swelling | Lesion size (mm3) | 2081.9 (1370.4–2592.6) | 1005.8 (762.0–1461.1) | 0.01 |
| Swelling (%) | 19.4 (13.7–26.1) | 11.5 (6.2–15.9) | 0.02 | ||
| Biomarkers | eNOS (ng/mL) | 816.4 (779.5–838.6) | 852.9 (846.9–859.3) | 0.03 | |
| ET-1 (ng/mL) | 373.7 (364.2–378.3) | 394.5 (371.3–405.8) | 0.09 |
Data presented as medians with interquartile range.
eNOS, endothelial nitric oxide synthase; ET-1, endothelin-1.