Table 4.
ASCVD(95% PI)* | NNT | Diabetes Mellitus(95% PI)* | NNH | |
---|---|---|---|---|
NCEP/ATP III | N=1334, #Event=144 | N=736, # Event=101 | ||
Moderate Intensity | −42.2(−57.3, −23.1) | 31.7 | 7.8(1.0,14.2) | 94.2 |
High Intensity | −55.4(−71.7,−36.8) | 24.1 | 22.0(4.9,38.8) | 33.5 |
−13.2 | 14.2 | |||
New ACC/AHA | N=3015, # Event =269 | N=2353, # Event =285 | ||
Moderate Intensity | −77.2(−104.2,−42.7) | 39.1 | 22.2(2.8, 40.6) | 106.2 |
High Intensity | −100.7(−129.4,−67.5) | 29.9 | 63.0(14.0, 112.5) | 37.4 |
−23.6 | 40.6 | |||
Newly Eligible | N=1742, # Event=127 | N= 1678, #Event =194 | ||
Moderate Intensity | −35.8(−48.1, −20.0) | 48.7 | 15.2(1.9, 27.9) | 110.7 |
High Intensity | −46.5(−59.4, −31.4) | 37.45 | 43.4(9.6, 78.4) | 38.6 |
Difference | −10.7 | 28.3 |
Note: 575 of the subcohort eligible under NCEP/ATP III and new ACC/AHA had diabetes mellitus; 23, 87 and 64 participants of the NCEP/ATP III, new ACC/AHA and newly eligible subcohorts had missing data on incident diabetes mellitus.
ASCVD: Indicates atherosclerotic cardiovascular disease, PI: Predicted interval, NNT: Number needed to treat, NNH: Number needed to harm
To obtain percent reduction in ASCVD events or T2DM caused = [(absolute number divided by #Event) × 100%]