Table 2.
Clinical studies using T1 mapping to evaluate myocardial fibrosis
| Author and Date |
Disease | Technique | Sample size (Cases/ Controls) |
Conclusions |
|---|---|---|---|---|
| Messroghli 2007 [42] | Acute or chronic | MOLLI | 24/24 | In acute and chronic infarction, pre contrast T1 values were higher than T1 values in remote myocardium |
| Maceira 2005 [46] | Amyloidosis | LL | 22/16 | Subepicardial post contrast T1 values were significantly reduced in amyloid compared with controls |
| Broberg 2010 [64] | Adult congenital heart disease | LL | 50/14 | Cases of adult congenital heart disease had elevated fibrosis index |
| Flett 2010 [65] | Aortic stenosis/HCM | LL | 18/8 (aortic stenosis). 8/8 (HCM) | A high correlation was seen between T1 mapping with equilibrium contrast cardiac imaging and histologic samples of aortic stenosis and HCM |
| Gai 2011 [66] | Type 1 Diabetes | LL | 19/13 | A significant difference was seen in post contrast T1 values between those at low risk for diabetes compared with those at high risk |
| Ugander 2012 [49] | NICM/ prior MI | MOLLI | 30/11, 36/11 | ECV is increased in those with prior MI and NICM |
| Bauner 2012 [52] | Chronic MI | MOLLI | 26/26 | A significant difference is seen in post contrast T1 values in chronically infarcted myocardium compared to healthy myocardium |
| Turkbey 2012 [67] | Myotonic muscular dystrophy | LL | 33/13 | Lower post contrast T values were seen in myotonic muscular dystrophy than in controls |
| Dass 2012 [68] | HCM/DCM | ShMOLLI | 28/12 (HCM), 18/12 (DCM) | Cases with HCM or DCM had higher pre contrast T1 times than controls |
| Messroghli 2003 [41] | Acute MI | LL | 8/8 | Post contrast T1 values in acute MI were significantly reduced compared to normal myocardium |
Note: MOLLI = modified look locker inversion, LL = look locker, ShMOLLI – short modified look locker version, MI = myocardial infarction, HCM = hypertrophic cardiomyopathy, DCM – dilated cardiomyopathy, NICM = non ischemic cardiomyopathy.