Table 3. Clinical Activity in Nivolumab-Treated Patients.☆.
Variable | All Patients (N = 23) | Failure of Both Stem-Cell Transplantation and Brentuximab (N = 15) | No Stem-Cell Transplantation and Failure of Brentuximab (N = 3) | No Brentuximab Treatment (N = 5)† |
---|---|---|---|---|
Best overall response — no. (%) | ||||
Complete response | 4 (17) | 1 (7) | 0 | 3 (60) |
Partial response | 16 (70) | 12 (80) | 3 (100) | 1 (20) |
Stable disease | 3 (13) | 2 (13) | 0 | 1 (20) |
Progressive disease | 0 | 0 | 0 | 0 |
Objective response | ||||
No. of patients | 20 | 13 | 3 | 4 |
Percent of patients (95% CI) | 87 (66–97) | 87 (60–98) | 100 (29–100) | 80 (28–99) |
Progression-free survival at 24 wk — % (95% CI)‡ | 86 (62–95) | 85 (52–96) | NC§ | 80 (20–97) |
Overall survival — wk | ||||
Median | NR | NR | NR | NR |
Range at data cutoff¶ | 21–75 | 21–75 | 32–55 | 30–50 |
NC denotes not calculated, and NR not reached.
In this group, two patients had undergone autologous stem-cell transplantation and three had not.
Point estimates were derived from Kaplan–Meier analyses; 95% confidence intervals were derived from Greenwood's formula.
The estimate was not calculated when the percentage of data censoring was above 25%.
Responses were ongoing in 11 patients.