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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: N Engl J Med. 2014 Dec 6;372(4):311–319. doi: 10.1056/NEJMoa1411087

Table 3. Clinical Activity in Nivolumab-Treated Patients..

Variable All Patients (N = 23) Failure of Both Stem-Cell Transplantation and Brentuximab (N = 15) No Stem-Cell Transplantation and Failure of Brentuximab (N = 3) No Brentuximab Treatment (N = 5)
Best overall response — no. (%)
 Complete response 4 (17) 1 (7) 0 3 (60)
 Partial response 16 (70) 12 (80) 3 (100) 1 (20)
 Stable disease 3 (13) 2 (13) 0 1 (20)
 Progressive disease 0 0 0 0
Objective response
 No. of patients 20 13 3 4
 Percent of patients (95% CI) 87 (66–97) 87 (60–98) 100 (29–100) 80 (28–99)
Progression-free survival at 24 wk — % (95% CI) 86 (62–95) 85 (52–96) NC§ 80 (20–97)
Overall survival — wk
 Median NR NR NR NR
 Range at data cutoff 21–75 21–75 32–55 30–50

NC denotes not calculated, and NR not reached.

In this group, two patients had undergone autologous stem-cell transplantation and three had not.

Point estimates were derived from Kaplan–Meier analyses; 95% confidence intervals were derived from Greenwood's formula.

§

The estimate was not calculated when the percentage of data censoring was above 25%.

Responses were ongoing in 11 patients.