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A) Depiction of the SCF E3 ligase complex. The complex contains a cullin (which is NEDDylated when active) which binds a RING domain as well as the adaptor Skp1. Skp1 also binds various F box proteins (such asβTrCP, Cdc4 and Skp2) which function as the substrate interaction motif, binding target proteins which are ubiquitinated. B) Inhibitors of SCF E3 ligases. The specific E3 inhibited is shown in parentheses.
