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. 2015 Mar 1;32(5):342–352. doi: 10.1089/neu.2014.3548

FIG. 4.

FIG. 4.

Detection of tau by enhanced immunoassay using multi-arrayed fiberoptics coupled to rolling circle amplification (a-EIMAF) in rat serum following severe traumatic brain injury. Adult male Sprague-Dawley rats were subjected to controlled cortical impact and blood was collected at various time points as indicated. The levels of T-tau and P-tau in serum was determined by a-EIMAF. Statistical analysis (t-test) was based on comparison to naïve rats. *p<0.001; **p<0.0001; ***p<0.00001.