FIG. 5.

Detection of tau by enhanced immunoassay using multi-arrayed fiberoptics coupled to rolling circle amplification (a-EIMAF) in mouse serum following severe traumatic brain injury. At Days 1 (D1), 3 (D3), and 7 (D7) post–controlled cortical impact (CCI) or sham treatment, blood was collected and the serum was assayed for T-tau and P-tau by a-EIMAF. The levels of T-tau and P-tau in the sham-treated mice at D1 (shown), D3, and D7 did not change significantly. Statistical analysis (t-test) was based on comparison to sham-treated mice. *p<0.01; **p<0.001; ***p<0.00001.