Table 2.
Summary of noncompartmental analysis
| Parameter (unit) | Moxifloxacin 400 mg
|
Moxifloxacin 800 mg
|
P-valuea |
|---|---|---|---|
| Mean ± SD | Mean ± SD | ||
| Normalized Cmax (ng/mL/mg) | 5.81±1.29 | 5.28±0.97 | 0.0140 |
| Normalized AUClast (ng*h/mL/mg) | 62.31±14.64 | 63.38±13.22 | 0.5803 |
| Normalized AUCinf (ng*h/mL/mg) | 83.33±23.10 | 84.73±19.99 | 0.6155 |
| Tmax (h)b | 1 (1–4) | 3 (1–4) | – |
| t1/2 (h) | 11.87±1.62 | 11.70±1.71 | 0.5349 |
| CL/F (L/h) | 12.80±3.09 | 12.42±2.79 | 0.1874 |
| Vd/F (L) | 214.60±43.00 | 206.20±39.49 | 0.1246 |
Notes:
a
Paired t-test.
b
Median (min–max).
Abbreviations: AUCinf, area under the plasma concentration–time curve from zero extrapolated to infinite time; AUClast, area under the plasma concentration–time curve from zero until last measurable concentration; CL/F, apparent clearance; Cmax, maximum plasma concentration; SD, standard deviation; t1/2, half-life; Tmax, time to maximum plasma concentration; Vd/F, apparent volume of distribution.