Table S2.
QTc intervals (ms) predicted by the final model (moxifloxacin 800 mg)
| Time (h) | QTc interval (mean and 95% CI)
|
|||
|---|---|---|---|---|
| Baseline | Placebo | Drug + placebo | Drug effect only | |
| 0 | 407.4 (400.6–414.1) | – | – | – |
| 1 | 407.0 (400.3–413.6) | 401.8 (395.4–408.2) | 416.8 (410.0–423.7) | 421.9 (414.6–429.2) |
| 2 | 407.9 (401.4–414.4) | 403.1 (396.8–409.4) | 420.9 (414.5–427.3) | 425.7 (418.8–432.7) |
| 3 | 409.1 (402.6–415.5) | 404.5 (398.3–410.8) | 422.3 (416.1–428.6) | 426.9 (420.1–433.6) |
| 4 | 408.8 (402.3–415.3) | 404.5 (398.2–410.8) | 421.8 (415.6–428.0) | 426.1 (419.4–432.8) |
| 6 | 404.4 (398.0–410.7) | 400.5 (394.4–406.7) | 416.6 (410.6–422.6) | 420.4 (414.0–426.8) |
| 8 | 403.6 (397.7–409.6) | 400.2 (394.4–406.0) | 414.9 (409.2–420.6) | 418.3 (412.2–424.4) |
| 12 | 400.9 (395.0–406.8) | 398.1 (392.3–403.9) | 410.4 (404.7–416.2) | 413.3 (407.3–419.2) |
| 16 | 405.1 (399.1–411.1) | 402.8 (396.8–408.8) | 413.3 (407.3–419.2) | 415.6 (409.5–421.7) |
| 24 | 407.4 (400.6–414.1) | 405.7 (399.0–412.3) | 413.3 (406.7–419.9) | 415.0 (408.3–421.7) |
Abbreviations: CI, confidence interval; QTc, corrected QT.