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. 2015 Jan 24;12:14. doi: 10.1186/s12974-014-0223-2

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© Hernandez-Encinas et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Regulation by C/EBPβ of the activity of the mouse C3 promoter. (A) RT-PCR analysis of C3 mRNA content in the hippocampus of C/EBPβ ^+/+ and C/EBPβ ^−/− mice. The graphic shows the mean ± SD of three different experiments. **P <0.01. (B, C) Analysis, by transient transfection in GL261 cells, of the effect of different deletions (B) and point mutations (C) on the activity of C3 promoter. Data represent the mean ± SD of luciferase activity determined in triplicate in at least three independent experiments. ***P <0.001 versus whole (B) or non-mutated (C) C3 promoter; #P <0.05, ###P <0.001 versus C3 basal promoter activity. (D) Representative image of ChIP analysis of C/EBPβ binding to the endogenous C3 promoter in primary astrocytes. DNA before immunoprecipitation was used as positive control (Input).